Basic Information
VIS ID
TVIS10006694
Fusion event
HBV-chr4 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1827
Integrated sequence
TCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATT| |TGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAG
Host Sequence
Chromosome
chr4
Cytoband
p15.31
Reference genome
GRCh38
Start
19740344 (Hg38)
End
19740344 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA4D
Nearest miRNA
hsa-mir-12113/Upstream/6112387; hsa-mir-12115/Downstream/787931;
Nearest TSS
ENST00000502981/Upstream/283350; ENST00000508824/Downstream/14247;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1717694, chr4-CpG: 284/Downstream/511309
Nearby gene
SLIT2(+513219) ;
Nearest cancer related gene
SLIT2(TSG, +513219) ;
Upstream sequence
AACAGTATCTCCATTTT
Junction sequence
AACAGTATCTCCATTTTAAAAAGTTGCATGGTGCTGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate