Basic Information
VIS ID
TVIS10006698
Fusion event
HBV-DUBR integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1823
Integrated sequence
AGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTA| |TATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCG
Host Sequence
Chromosome
chr3
Cytoband
q13.12
Reference genome
GRCh38
Start
107279641 (Hg38)
End
107279641 (Hg38)
Location type
Intron
Target gene
DUBR
Nearest miRNA
hsa-let-7g/Upstream/3755525; hsa-mir-12124/Downstream/2323187;
Nearest TSS
ENST00000440867/Upstream/38619; ENST00000609969/Downstream/43094;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/38563, chr3-CpG: 107/Downstream/151332
Upstream sequence
CAATTTTGAAACAGCAGAAT
Junction sequence
CAATTTTGAAACAGCAGAATAAGTTGCATGGTGNTGGTGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate