VISDB Viral Integration Site DataBase

VIS ID

TVIS10006705

Fusion event

HBV-TGFBR2 integration

Validated

Yes

Detection method

invPCR +Sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Perfect

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1803

Integrated sequence

AGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTA| |GCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAG

Chromosome

chr3

Cytoband

p24.1

Reference genome

Start

End

30662750 (Hg38)

Location type

Intron

Target gene

miRNAs that regulate target gene

hsa-mir-21-5p ; hsa-mir-20a-5p ; hsa-mir-204-5p ; hsa-mir-17-5p ; hsa-mir-18a-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-590-5p ; hsa-mir-92a-3p ; hsa-mir-302b-3p ; hsa-mir-372-3p ; hsa-mir-106a-5p ; hsa-mir-370-3p ; hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-34b-5p ; hsa-mir-373-3p ; hsa-mir-145-5p ; hsa-mir-630 ; hsa-mir-211-5p ; hsa-mir-655-3p ; hsa-mir-130a-3p ; hsa-mir-142-5p ; hsa-mir-106b-5p ; hsa-mir-301a-3p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-548c-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-5590-3p ; hsa-mir-1276 ; hsa-mir-216a-5p ; hsa-mir-551b-5p ; hsa-mir-1200 ; hsa-mir-544b ; hsa-mir-5095 ; hsa-mir-6758-3p ; hsa-mir-7151-3p ; hsa-mir-33a-3p ; hsa-mir-409-3p ; hsa-mir-610 ; hsa-mir-3978 ; hsa-mir-940 ; hsa-mir-6808-5p ; hsa-mir-6893-5p ; hsa-mir-34a-5p ; hsa-mir-34c-5p ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-449c-5p ; hsa-mir-1253 ; hsa-mir-1910-3p ; hsa-mir-2682-5p ; hsa-mir-6511a-5p ; hsa-mir-6770-5p ; hsa-mir-6806-5p ; hsa-mir-1827 ; hsa-mir-4316 ; hsa-mir-9-5p ; hsa-mir-582-5p ; hsa-mir-101-3p ; hsa-mir-595 ; hsa-mir-4438 ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4324 ; hsa-mir-574-5p ; hsa-mir-147a ; hsa-mir-6867-5p ; hsa-mir-6818-5p ; hsa-mir-4732-5p ; hsa-mir-6832-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-488-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-6777-3p ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-7159-5p ; hsa-mir-505-3p ; hsa-mir-7162-3p ; hsa-mir-4649-3p ; hsa-mir-3065-5p ; hsa-mir-3200-5p ; hsa-mir-7849-3p ; hsa-mir-606 ; hsa-mir-570-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-196a-5p ; hsa-mir-196b-5p ; hsa-mir-202-5p ; hsa-mir-181c-5p ; hsa-mir-520a-3p ; hsa-mir-23b-5p ; hsa-mir-302d-3p

Nearest miRNA

hsa-mir-12127/Upstream/4997811; hsa-let-7g/Downstream/498954;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/55361, chr3-CpG: 29/Downstream/231805

Nearest cancer related gene

TGFBR2(TSG, No orient, 0)

Upstream sequence

CTAGAAAATTATCATGGGC

Junction sequence