Basic Information
VIS ID
TVIS10006727
Fusion event
HBV-ADGRB1 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1755
Integrated sequence
GTGCGCCCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGA| |CGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGT
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh38
Start
142522537 (Hg38)
End
142522537 (Hg38)
Location type
Intron
Fragile sites / regions
FRA8D
Target gene
ADGRB1
Nearest miRNA
hsa-mir-1204/Upstream/346119; hsa-mir-10400/Downstream/1210546;
Nearest TSS
ENST00000518652/Upstream/43417; ENST00000518812/Downstream/20964;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/6004, chr8-CpG: 22/Downstream/10778
Upstream sequence
TCTGTTGGGGGCTTCAG
Junction sequence
TCTGTTGGGGGCTTCAGATCTCCTCCCCCAACTCCTC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate