Basic Information
VIS ID
TVIS10006734
Fusion event
HBV-chr2 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1802
Integrated sequence
GAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCT| |AGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTA
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh38
Start
43087375 (Hg38)
End
43087375 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1301/Upstream/7615889; hsa-mir-10b/Downstream/4290300;
Nearest TSS
ENST00000437798/Upstream/43593; ENST00000623515/Downstream/15316;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/18873, chr2-CpG: 45/Downstream/13423
Nearby gene
LINC01819(-47832) ; ZFP36L2(+136943) ;
Nearest cancer related gene
ZFP36L2(TSG, +136943) ;
Downstream sequence
CCCAGAAGATTCCCTGGATCC
Junction sequence
CTGTAGGCATAAATTGGTCTACCCAGAAGATTCCCTGGATCC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate