VISDB Viral Integration Site DataBase

VIS ID

TVIS10006747

Fusion event

HBV-CCN6 integration

Validated

Yes

Detection method

invPCR +Sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Perfect

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1783

Integrated sequence

GACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGAT| |CCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTG

Chromosome

chr6

Cytoband

q21

Reference genome

Start

End

112053921 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-378a-5p ; hsa-mir-6131 ; hsa-mir-4755-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3663-5p ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-3653-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-7853-5p ; hsa-mir-105-5p

Nearest miRNA

hsa-mir-10398/Upstream/5269701; hsa-mir-1202/Downstream/7015126;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/180270, chr6-CpG: 49/Downstream/33282

Nearby gene

FYN(-180469) ; CCN6(+153) ;

Nearest cancer related gene

CCN6(TSG, No orient, 0)

Downstream sequence

CTAGAGAGGACCCGGAG

Junction sequence