Basic Information
VIS ID
TVIS10006748
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1718
Integrated sequence
ATGAGAAGGCACAGACGGGGAGTCCGCGTAAAGAGAGGTGCGCCCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCC| |CGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACG
Host Sequence
Chromosome
chr1
Cytoband
p22.3
Reference genome
GRCh38
Start
87599199 (Hg38)
End
87599199 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA1D
Nearest miRNA
hsa-mir-101-1/Upstream/1241512; hsa-mir-11399/Downstream/6247633;
Nearest TSS
ENST00000473358/Upstream/227544; ENST00000436111/Downstream/306515;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/263650, chr1-CpG: 63/Downstream/863401
Nearby gene
CYTOR(-177688) ; MIR4435-2(+30560) ;
Upstream sequence
TAGAAAAAAAACAGAGAA
Junction sequence
TAGAAAAAAAACAGAGAAAGTCTTTGAAGTATGCCTCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate