Basic Information
VIS ID
TVIS10006758
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1792
Integrated sequence
GGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGC| |AGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAA
Host Sequence
Chromosome
chr1
Cytoband
q21.3
Reference genome
GRCh38
Start
152568994 (Hg38)
End
152568994 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA1F
Nearest miRNA
hsa-mir-101-1/Upstream/1023103; hsa-mir-1182/Downstream/1120711;
Nearest TSS
ENST00000473358/Upstream/2222; ENST00000333881/Downstream/11510;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/53200, chr1-CpG: 111/Downstream/692002
Nearby gene
LCE3E(-2241) ; LCE3D(+10389) ;
Downstream sequence
TTTTTTTTCTTTAGCACTTTG
Junction sequence
TATTAGGAGGCTGTAGGCATTTTTTTTTCTTTAGCACTTTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate