VISDB Viral Integration Site DataBase

VIS ID

TVIS10006759

Fusion event

HBV-VAV2 integration

Validated

Yes

Detection method

invPCR +Sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Perfect

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1828

Integrated sequence

CGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTT| |GCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGA

Chromosome

chr9

Cytoband

q34.2

Reference genome

Start

End

133971570 (Hg38)

Location type

Intron

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-877-3p ; hsa-mir-193b-3p ; hsa-mir-320a ; hsa-let-7a-5p ; hsa-mir-148a-3p ; hsa-mir-218-5p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-6090 ; hsa-mir-6081 ; hsa-mir-6827-5p ; hsa-mir-6124 ; hsa-mir-873-5p ; hsa-mir-3192-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-331-3p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6165 ; hsa-mir-4524b-3p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-1273d ; hsa-mir-4493 ; hsa-mir-4753-5p

Nearest miRNA

hsa-let-7a-1/Upstream/919511; hsa-mir-126/Downstream/407841;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/2300, chr9-CpG: 18/Downstream/7728

Nearest cancer related gene

VAV2(OG, No orient, 0)

Downstream sequence

GTGACACTGGCCTCCTGCCCAG

Junction sequence