Basic Information
VIS ID
TVIS10006761
Fusion event
HBV-RTL4 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1817
Integrated sequence
CCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAAC| |GATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTAT
Host Sequence
Chromosome
chrX
Cytoband
q23
Reference genome
GRCh38
Start
112390159 (Hg38)
End
112390159 (Hg38)
Location type
Intron
Target gene
RTL4
Nearest miRNA
hsa-let-7f-2/Upstream/2307941; hsa-mir-105-1/Downstream/390559;
Nearest TSS
ENST00000429181/Upstream/307383; ENST00000340433/Downstream/64341;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/9345, chrX-CpG: 25/Downstream/450177
Downstream sequence
ATTTAGGATCGTGGCCAGGTG
Junction sequence
GGTCTGCGCACCAGCACCATATTTAGGATCGTGGCCAGGTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate