Basic Information
VIS ID
TVIS10006769
Fusion event
HBV-chr22 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1784
Integrated sequence
ACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATC| |CAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGC
Host Sequence
Chromosome
chr22
Cytoband
q13.31
Reference genome
GRCh38
Start
46083145 (Hg38)
End
46083145 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA22A
Nearest miRNA
hsa-mir-1249/Upstream/322547; hsa-let-7a-3/Downstream/7899;
Nearest TSS
ENST00000624155/Upstream/2833; ENST00000435439/Downstream/2852;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/10497, chr22-CpG: 17/Downstream/2790
Nearby gene
PRR34-AS1(-24623) ; MIRLET7BHG(+2851) ;
Upstream sequence
CTTTTAAGACCCCACATG
Junction sequence
CTTTTAAGACCCCACATGAGCCTCCTAATACAAAGACC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate