Basic Information
VIS ID
TVIS10006770
Fusion event
HBV-chr4 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1826
Integrated sequence
GTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATAT| |TTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCA
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
GRCh38
Start
34525030 (Hg38)
End
34525030 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA4D
Nearest miRNA
hsa-mir-12113/Upstream/5705362; hsa-mir-1243/Downstream/1901336;
Nearest TSS
ENST00000502981/Upstream/255283; ENST00000514737/Downstream/132576;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/3801810, chr4-CpG: 100/Downstream/1718979
Nearby gene
LOC101928622(-485137) ;
Downstream sequence
AGAAACCTGTTCAAATGTA
Junction sequence
ACCAGCACCATGCAACTTTTAGAAACCTGTTCAAATGTA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate