Basic Information
VIS ID
TVIS10006771
Fusion event
HBV-chr7 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1977
Integrated sequence
CTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGAGGAGCCGAAAAGGTTCCACGCATGCGCTGATGGCCCATGACCAAGCCCC| |AGCCAGTGGGGGTTGCGTCAGCAAACACTTGGCACAGACCTGGCCGTTGCCGGGCAACGGGGTAAAGGTTCAGGTATTGTTTACACAGAAAGGCCTTGTA
Host Sequence
Chromosome
chr7
Cytoband
p21.1
Reference genome
GRCh38
Start
19465891 (Hg38)
End
19465891 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1302-6/Upstream/1338582; hsa-mir-10399/Downstream/239467;
Nearest TSS
ENST00000635602/Upstream/112357; ENST00000590912/Downstream/234444;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/320481, chr7-CpG: 44/Downstream/242883
Nearby gene
FERD3L(-320470) ; TWISTNB(+229570) ;
Upstream sequence
CTAGGGTTAATTATAAGCAG
Junction sequence
CTAGGGTTAATTATAAGCAGAGGAAAGAAGTCAGAAGGCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate