CUL1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006772
Fusion event
HBV-CUL1 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1796
Integrated sequence
ACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCA| |CAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAG
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh38
Start
148773668 (Hg38)
End
148773668 (Hg38)
Location type
Intron
Fragile sites / regions
FRA7I
Target gene
CUL1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-27b-3p ; hsa-mir-100-5p ; hsa-mir-27a-3p
Nearest miRNA
hsa-mir-10399/Upstream/1395547; hsa-mir-153-2/Downstream/2464753;
Nearest TSS
ENST00000635602/Upstream/43669; ENST00000627071/Downstream/38155;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/73758, chr7-CpG: 34/Downstream/9369
Nearest cancer related gene
CUL1(TSG, No orient, 0)
Upstream sequence
CGCTGCGTGTGTCTTCTC
Junction sequence
CGCTGCGTGTGTCTTCTCATTTATGCCTACNGCCTCCT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
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