Basic Information
VIS ID
TVIS10006774
Fusion event
HBV-chr5 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1709
Integrated sequence
GTCCGGCAGATGAGAAGGCACAGACGGGGAGTCCGCGTAAAGAGAGGTGCGCCCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCC| |AAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCC
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
GRCh38
Start
136506566 (Hg38)
End
136506566 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/703491; hsa-mir-103a-1/Downstream/1141006;
Nearest TSS
ENST00000502646/Upstream/39889; ENST00000502421/Downstream/228361;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/149212, chr5-CpG: 134/Downstream/991761
Nearby gene
TRPC7(-141090) ; SPOCK1(+468731) ;
Downstream sequence
nnGGCTAGGGACCTGGAGTCTG
Junction sequence
GACCGACCTTGAGGCATACTCCAnnGGCTAGGGACCTGGAGTCTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate