Basic Information
VIS ID
TVIS10006790
Fusion event
HBV-MMS22L integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
2178
Integrated sequence
GTTGGCGAGAAAGTGAAAGCCTGCTTAGATTGAATACATGCATACAAAGGCATCAACGCAGGATAACCACATTGTGTAAAAGGGGCAGCAAAACCCAAAA| |GACCCACAATTCGTTGACATACTTTCCAATCAATAGGCCTGTTAATAGGAAGTTTTCTAAAACATTCTTTGATTTTTTGTATGATGTGTTCTTGTGGCAA
Host Sequence
Chromosome
chr6
Cytoband
q16.1
Reference genome
GRCh38
Start
97144649 (Hg38)
End
97144649 (Hg38)
Location type
Intron
Target gene
MMS22L
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-155-5p ; hsa-mir-128-3p ; hsa-mir-1-3p ; hsa-mir-101-3p ; hsa-mir-27a-3p ; hsa-mir-320a ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-548as-3p ; hsa-mir-6835-3p ; hsa-mir-5692a ; hsa-mir-657 ; hsa-mir-3665 ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-154-5p ; hsa-mir-144-3p ; hsa-mir-3613-5p ; hsa-mir-196b-5p ; hsa-mir-196a-5p ; hsa-mir-624-3p ; hsa-mir-4511 ; hsa-mir-548b-3p ; hsa-mir-8485 ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-4668-5p ; hsa-mir-4789-5p ; hsa-mir-466 ; hsa-mir-27b-3p ; hsa-mir-1227-3p ; hsa-mir-1247-3p ; hsa-mir-1273g-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-3612 ; hsa-mir-3929 ; hsa-mir-4252 ; hsa-mir-4327 ; hsa-mir-4419b ; hsa-mir-4478 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-4649-3p ; hsa-mir-4722-5p ; hsa-mir-485-5p ; hsa-mir-5690 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6808-5p ; hsa-mir-6884-5p ; hsa-mir-6893-5p ; hsa-mir-7160-5p ; hsa-mir-890 ; hsa-mir-940
Nearest miRNA
hsa-mir-10398/Upstream/5622912; hsa-mir-1202/Downstream/879882;
Nearest TSS
ENST00000381078/Upstream/80021; ENST00000574739/Downstream/17396;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/219662, chr6-CpG: 53/Downstream/138171
Nearest cancer related gene
MMS22L(OG, No orient, 0)
Upstream sequence
GGTATTTAGGGAAAGTGGC
Junction sequence
GGTATTTAGGGAAAGTGGCTATGGNCCTAAAAATCAGAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate