Basic Information
VIS ID
TVIS10006807
Fusion event
HBV-chr18 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1804
Integrated sequence
GTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAG| |CAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGG
Host Sequence
Chromosome
chr18
Cytoband
q21.33
Reference genome
GRCh38
Start
63467741 (Hg38)
End
63467741 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/5016583; hsa-mir-5011/Downstream/3613843;
Nearest TSS
ENST00000575820/Upstream/45258; ENST00000424602/Downstream/9020;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/44617, chr18-CpG: 63/Downstream/468425
Nearby gene
VPS4B(-45222) ; SERPINB5(+9169) ;
Nearest cancer related gene
SERPINB5(TSG, +9169) ;
Upstream sequence
CTTTCTACTCGATGGGTGCCAA
Junction sequence
CTTTCTACTCGATGGGTGCCAAGCAGACCAATTTATGCCTAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate