Basic Information
VIS ID
TVIS10006813
Fusion event
HBV-chr8 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1805
Integrated sequence
TCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGC| |AGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGA
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh38
Start
31564713 (Hg38)
End
31564713 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/1607365; hsa-mir-10400/Downstream/9706335;
Nearest TSS
ENST00000518652/Upstream/67290; ENST00000614767/Downstream/74673;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/531004, chr8-CpG: 142/Downstream/74296
Nearby gene
WRN(-391611) ; NRG1(+75038) ;
Downstream sequence
AGCTACCATTAGACCCAGC
Junction sequence
TAGGCATAAATTGGTCTGCGAGCTACCATTAGACCCAGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate