VISDB Viral Integration Site DataBase

VIS ID

TVIS10006825

Fusion event

HBV-KMT2B integration

Validated

Yes

Detection method

Alu PCR and sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2015

PubMed ID

Virus name

HBV

Reference genome

Not given

Start

1808

Chromosome

chr19

Cytoband

q13.12

Reference genome

Start

End

35721735 (Hg38)

Orient

+

Location type

Exon 3

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-7515 ; hsa-mir-302a-5p ; hsa-mir-3154 ; hsa-mir-6782-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-5692a ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-20b-5p ; hsa-mir-153-3p ; hsa-mir-1224-3p ; hsa-mir-1294 ; hsa-mir-1914-3p ; hsa-mir-214-3p ; hsa-mir-31-5p ; hsa-mir-3184-5p ; hsa-mir-3619-5p ; hsa-mir-3689d ; hsa-mir-423-5p ; hsa-mir-4316 ; hsa-mir-4426 ; hsa-mir-4440 ; hsa-mir-4459 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-4688 ; hsa-mir-4722-5p ; hsa-mir-5194 ; hsa-mir-6085 ; hsa-mir-6165 ; hsa-mir-6734-5p ; hsa-mir-6738-5p ; hsa-mir-6743-5p ; hsa-mir-6789-5p ; hsa-mir-6813-5p ; hsa-mir-6851-5p ; hsa-mir-761 ; hsa-mir-7704 ; hsa-mir-885-3p

Nearest miRNA

hsa-mir-10395/Upstream/376438; hsa-let-7e/Downstream/3687888;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/2041, chr19-CpG: 24/Downstream/1991

Upstream sequence

tggcccttctctgtgctagttccctgtccctatcttccttttttttttttttttatttttgagaccgagtctcactttgtccaggctggagtgcagtggc

Downstream sequence

AAGAGAGCCAAAGTGCAGCTATTCAAGATCGATCAGCAGCAGCAGCAGAAGGTGGCAGCTTCCATGCCGGTGAGTGTGGTCCCTGGGCCCAGCGGCACAC

Target sequence

AAGAGAGCCAAAGTGCAGCTATTCAAGATCGATCAGCAGCAGCAGCAGAAGGTGGCAGCTTCCATGCCGGTGAGTGTGGTCCCTGGGCCCAGCGGCACACCCAGCCATCCAGCCTCCATTCTTTGCAACCCCCTAACCTTCCGCCTCCTTGGACACTTTCCAGCATTGCGGGGAACCCTCAGAACCTGCCTTTCTGTGATCCCCCACCTTCCTTTGTTCCTCCCCAGAcctggcccttctctgtgctagttccct