Basic Information
VIS ID
TVIS10006849
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
B2
Reference genome
JQ688405
Region type
Polymerase,Pre-S1/S2/S, Pre-S2/S, S
Start
3070
Integrated sequence
GATTGGGACCTCAACCCGCACAAGGACAACTGGCCGGACGCCAACAAGGTGGGAGTGGGAGCATTCGGGCCAGGGTTCACCCCTCCCCATGGGGGACTGT| |TGGGGTGGAGCCCTCAGGCTCAGGGCCTACTCACAACTGTGCCAGCAGCTCCTCCTCCTGCCTCCACCAATCGGCAGTCAGGAAGGCAGCCTACTCCCTT
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
25392522/25066031 (Hg38)
End
25392522/25066031 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA1A
Nearest miRNA
hsa-mir-12136/Upstream/42445; hsa-mir-101-1/Downstream/840331;
Nearest TSS
ENST00000473358/Upstream/95166; ENST00000455902/Downstream/47088;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/133517, chr1-CpG: 45/Downstream/166041
Nearby gene
SYF2
Nearest cancer related gene
RUNX3(TSG, No orient)
Upstream sequence
AACAGCCAGCATGCCTGGAGAGCTTTTCTGCACCCAGCACGGTTTGGGCTCTTTTCAAGTGACGCTGCGTGTGGCCCGGCCAGCTCACCACACTCACACG
Downstream sequence
TGCCTCTCATGCCTCACACCCGCAGGGCGCCCACACCCACTTCCACACTCACACCCGCCCACCCCCCTGCTCACAAGTGCGTCCTCCCAGGCCCCAGGCC
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
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