Basic Information
VIS ID
TVIS10006852
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
JQ688404
Region type
pre-core/core, X protein
Start
1828
Integrated sequence
ACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCAC| |CTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTG
Host Sequence
Chromosome
chr1
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
96375021/95909465 (Hg38)
End
96375021/95909465 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA1M
Nearest miRNA
hsa-mir-101-1/Upstream/1365686; hsa-mir-11399/Downstream/2135777;
Nearest TSS
ENST00000473358/Upstream/166369; ENST00000634962/Downstream/28436;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/674879, chr1-CpG: 64/Downstream/812081
Nearby gene
PTBP2
Upstream sequence
ttctatgtcttcttttgagaaacatctgttcagatcatttgtgcatttgatattcaggttgtttcttgttgttgagatgtttgagttctttaaatattct
Downstream sequence
ggatattaatcctctgtcagattaatagtttgcaaatattttcttccatcctgtaggctgacttttcacttgttatttcctttaatgtacagaagtcttt
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate