Basic Information
VIS ID
TVIS10006853
Fusion event
HBV-chr6 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
JQ688404
Region type
pre-core/core, X protein
Start
1820
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAA
Host Sequence
Chromosome
chr6
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
143730976/143409839 (Hg38)
End
143730976/143409839 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/2725956; hsa-mir-1202/Downstream/7692836;
Nearest TSS
ENST00000381078/Upstream/244895; ENST00000367592/Downstream/32138;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/348591, chr6-CpG: 40/Downstream/40634
Nearby gene
ADAT2(No orient, 12993)
Upstream sequence
cagagtagttttaatataatttttaagcattctaggattttcagaatagtaaataatcactggcttcaactgaaagtcactggatacattggcctctaac
Downstream sequence
cacctaccccagaggctgaggcaggggaatggcgtgaaccagggaggcggagcttgcagtgagcctagaccgagccactgtgctccagcctgggcaatag
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate