Basic Information
VIS ID
TVIS10006861
Fusion event
HBV-chr19 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
B2
Reference genome
JQ688405
Region type
pre-core/core
Start
1822
Integrated sequence
TTAATGAGTGGGAGGAGTTGGGGGAGGAGGTTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTGTGTTCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAG
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30278016/29787109 (Hg38)
End
30278016/29787109 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/9387755; hsa-let-7e/Downstream/5335591;
Nearest TSS
ENST00000633603/Upstream/71320; ENST00000586912/Downstream/24789;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/62422, chr19-CpG: 137/Downstream/24279
Nearby gene
C19orf12
Nearest cancer related gene
CCNE1(OG, No orient)
Upstream sequence
TATgagaccagcttgggcaacatggtgagaccttgctacaaaaaataaaaattggctggatgtggtggtgtgcgcctttagtcccagctgctcaggaggc
Downstream sequence
tgaggtgggaggatcgcttcagcccaaaaggtagaagctgcagtgagccatgaCAGTGCAGCCTTGTCTCAAAAAATAATAATAATAAAGATTGCAAAGG
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate