VISDB Viral Integration Site DataBase

VIS ID

TVIS10006869

Fusion event

HBV-DNAH17 integration

Validated

Yes

Detection method

Alu PCR and sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2015

PubMed ID

Virus name

HBV

Subtype

B2

Reference genome

Region type

Polymerase,

Start

2174

Integrated sequence

ATTCTGTGTTGGGGTGAGTTGATGAATCTAGCCACCTGGGTGGGAAGTAATTTGGAAGATCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAACGTTA| |ATATGGGCCTAAAAATCAGACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTGGGAGAGAAACTGTTCTTGAATATTTGGTGTCTTTTGGAGTGTG

Chromosome

chr17

Cytoband

q25.3

Reference genome

Start

End

76531764/78535682 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-4279 ; hsa-mir-4467 ; hsa-mir-8072 ; hsa-mir-4767 ; hsa-mir-3960 ; hsa-mir-1199-3p ; hsa-mir-1908-3p ; hsa-mir-1910-5p ; hsa-mir-503-5p ; hsa-mir-2278 ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-6780a-5p ; hsa-mir-450a-1-3p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-6799-5p ; hsa-mir-30c-1-3p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-8073 ; hsa-mir-6089 ; hsa-mir-221-5p ; hsa-mir-500a-5p ; hsa-mir-8081 ; hsa-mir-6790-5p ; hsa-mir-4658 ; hsa-mir-4758-5p ; hsa-mir-1238-5p ; hsa-mir-4745-5p ; hsa-mir-4481 ; hsa-mir-17-3p ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-4733-3p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-1911-3p

Nearest miRNA

hsa-mir-10226/Upstream/1138628; hsa-mir-1250/Downstream/1171494;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/32689, chr17-CpG: 155/Downstream/245746

Upstream sequence

CTCGCTGTAAATATATGTTATGACAAATCATACGTGTCCATTATTTTACAATTCAAACAACGCAGAAATGCATGAGAGGAAACGCCTGCAGCCACATCCC

Downstream sequence

TCTCCCCTCCCCTCCTTCCTCCCTTCCTGGTAAGCACTCACCCAGATTTTTGCTTGTTTAAGCAAATGAAACCATATTCTAAACATTGTTCTGTAACTTG