Fusion event
HBV-chr8 integration
Detection method
Alu PCR and sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
CATGTTGCTGTACAAAACCTACGGACGGAAACTGCACCTGTATTCCCATCCCATCATCTTGGGCTTTCGCAAAATACCTATGGGAGTGGGCCTCAGTCCG| |TTTCTCTTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTCTGGCTTTCAGTTATATGGATGATGTGGTTTTGGGGG
End
128764911/127752665 (Hg38)
Nearest miRNA
hsa-mir-12123/Upstream/2930607; hsa-mir-10400/Downstream/43297;
Nearest cancer related gene
MYC(OG, No orient, 11231)
Upstream sequence
AGTGTCAAAAGCCTGCTTTCTTACTTCTGTCCTAGCTAATTTTCTCCTCAATGACACAATCCAGAGAGAGACCATTTCTAGGGTGGCATACCTTCACAAA
Downstream sequence
cactgtactccttgctgggtgacagagcgagagtccatctaaaaaaaaaaGGGAGTGGGGTGGGGGCAAAGTCATGGTGCTGAATGTTAGGACACCGGAt
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.