Basic Information
VIS ID
TVIS10006873
Fusion event
HBV-chr8 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
JQ688404
Region type
pre-core/core
Start
1907
Integrated sequence
AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA| |TTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGC
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
60201121/59288562 (Hg38)
End
60201121/59288562 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/16392287; hsa-mir-10400/Downstream/2426226;
Nearest TSS
ENST00000518652/Upstream/168616; ENST00000522898/Downstream/305139;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/168375, chr8-CpG: 14/Downstream/885004
Nearby gene
CA8
Upstream sequence
ATATTTTTAAGGACTAAAAGGTAGACTATAAATGTTTATTGTTCTATACGTAATATAATAAGATATGAAAATAAACAAATGAGAACTTTGTATTAAAAGA
Downstream sequence
ggtgggtgtgtatgtgtgtgtgtttgtgtatgtAATCATTGGCATATAATAGCaatagcctaacttttattgagcaggtactatatttcagggactattc
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate