Basic Information
VIS ID
TVIS10006880
Fusion event
HBV-chr19 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
B2
Reference genome
JQ688405
Region type
Polymerase, X protein
Start
1807
Integrated sequence
TCAAAGACTGTGTGTTTAATGAGTGGGAGGAGTTGGGGGAGGAGGTTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTGTGTTCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr19
Cytoband
q13.42
Reference genome
GRCh37/hg19
Start
54182535/53679281 (Hg38)
End
54182535/53679281 (Hg38)
Location type
Promoter
Fragile sites / regions
FRA19A
Target gene
MIR515-1 ; MIR515-2 ; MIR519E
Nearest miRNA
hsa-let-7e/Upstream/196; hsa-mir-10394/Downstream/659;
Nearest TSS
ENST00000633603/Upstream/47225; ENST00000597619/Downstream/82680;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/30294, chr19-CpG: 23/Downstream/89205
Upstream sequence
tttttttgcaacacagggtctcttgcccaggctggagtgcggtgacacttccaacctagacctcttgggctcagttggtccctgcccccacccccTCCCC
Downstream sequence
Cttttttttctcttgagacagtctctctctgtggcccaggctggagtgcagtggtatgttctctgctcactgcaacctctgcctcccgagtagctggtat
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate