VISDB Viral Integration Site DataBase

VIS ID

TVIS10006882

Fusion event

HBV-TMEFF1 integration

Validated

Yes

Detection method

Alu PCR and sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2015

PubMed ID

Virus name

HBV

Subtype

B2

Reference genome

Region type

Polymerase,S

Start

391

Integrated sequence

CGTGTGTCTTGGCCAAAATTCGCAGTCCCAAATCTCCAGTCACTCACCAACCTGTTGTCCTCCAATTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGT| |TTTATCATCTTCCTCTGCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGAT

Chromosome

chr9

Cytoband

q31.1

Reference genome

Start

End

103256893/100494611 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-1250-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-548c-3p

Nearest miRNA

hsa-let-7a-1/Upstream/2265394; hsa-mir-12126/Downstream/6106317;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/20266, chr9-CpG: 38/Downstream/104062

Nearest cancer related gene

TMEFF1(TSG, No orient, 0)

Upstream sequence

gatcaatttggagagaaatgacatttcaaagatattgagtcttctaattcatgaacactgaatatgttcccttttatgagggtcttctttgatctttccc

Downstream sequence

AAACAGAGGAAGAATGAAGGAGGAAGGGACAGTGCCTACATATGAACACAGAgcgagggaggccaagaaatgtaggttatttagttgggtactttgtttc