Basic Information
VIS ID
TVIS10006884
Fusion event
HBV-chr8 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
JQ688404
Region type
Polymerase,S
Start
660
Integrated sequence
CTTGTTGCTGTACAAAACCTTCGGACGGAAACTGCACTTGTATTCCCATCCCATCATCCTGGGCTTTCGCAAGATTCCTATGGGAGTGGGCCTCAGTCCG| |TTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGG
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
128764911/127752665 (Hg38)
End
128764911/127752665 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/2930607; hsa-mir-10400/Downstream/43297;
Nearest TSS
ENST00000518652/Upstream/16071; ENST00000524165/Downstream/41868;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/13632, chr8-CpG: 94/Downstream/41170
Nearby gene
MYC(No orient, 11231)
Nearest cancer related gene
MYC(OG, No orient, 11231)
Upstream sequence
TTTATGGTGGTTAAGAAGACCAAGAGGGGAAGAAAATCTGTTAGGGCAATGTCAGCTTAAGAGAGAAGCTGAAATTATTTATTTTAGCACCTTATTTCTA
Downstream sequence
cactgtactccttgctgggtgacagagcgagagtccatctaaaaaaaaaaGGGAGTGGGGTGGGGGCAAAGTCATGGTGCTGAATGTTAGGACACCGGAt
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate