VISDB Viral Integration Site DataBase

VIS ID

TVIS10006893

Fusion event

HBV-UNC5D integration

Validated

Yes

Detection method

Alu PCR and sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2015

PubMed ID

Virus name

HBV

Subtype

B2

Reference genome

Region type

Polymerase,Pre-S2/S, S

Start

122

Integrated sequence

CTTCAAGATCCCAGAGTCAGGGCCCTGTACTTTCCTGCTGGTGGCTCCAGTTCAGGAACAGTGAGCCCTGCTCAGAATACTGTCTCTGCCATATCGTCAA| |TCTTATCGAAGACTGGGGACCCTGTACCGAACATGGAGAACATCGCATCAGGACTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGAC

Chromosome

chr8

Cytoband

p12

Reference genome

Start

End

35280417/35422899 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-4328 ; hsa-mir-129-5p

Nearest miRNA

hsa-mir-124-1/Upstream/5465551; hsa-mir-10400/Downstream/5848149;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/186306, chr8-CpG: 351/Downstream/2271527

Nearest cancer related gene

UNC5D(TSG, No orient, 0)

Upstream sequence

atttttttctatcccatggttggactgcaaattttccaaacttttatgctctgcttcacttttaaatgtaagttctagttttaggtcatttctttatgta

Downstream sequence

CACATGGGTAGATGTTATATTGGAGGCTCTCAAATGCCCCacagatgaagaaacaaagcctccacaagtttcagtgacttgcctcaggttatgcagttac