Basic Information
VIS ID
TVIS10006896
Fusion event
HBV-chr7 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
B2
Reference genome
JQ688405
Region type
Polymerase
Start
2803
Integrated sequence
ATCCAGAGTATGTAGTTAATCATTACTTCCAGACGCGACATTATTTACACACTCTTTGGAAGGCGGGGATCTTATATAAAAGAGAGTCCACACGTAGCGC| |CTCATTTTGCGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGAAAAGGCATGGGGACAAATCTTTCTGTCCC
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
63071018/63610640 (Hg38)
End
63071018/63610640 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA7J
Nearest miRNA
hsa-mir-1183/Upstream/6205550; hsa-mir-10399/Downstream/10450;
Nearest TSS
ENST00000635602/Upstream/216363; ENST00000450544/Downstream/282838;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/29650, chr7-CpG: 101/Downstream/16982
Nearby gene
MIR4283-1(No orient, 10450)
Upstream sequence
ACTGCAATGAATGAGAAAGACACAAAGACACAAAAAGGGGCTTTAAAATTTACCCAGGTACTCAAGGTCAGAAGAGGCAATAGGCACAAATTCCAGGAAA
Downstream sequence
ctggccaacatagcaaaacccagtctctactaaaaatacaaaaattagccaggcgtggtggtgggcacttgtaattccaactactcgggaggctgaggca
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate