Basic Information
VIS ID
TVIS10006901
Fusion event
HBV-chr7 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
B2
Reference genome
JQ688405
Region type
pre-core/core, X protein
Start
1822
Integrated sequence
TTAATGAGTGGGAGGAGTTGGGGGAGGAGGTTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTGTGTTCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAG
Host Sequence
Chromosome
chr7
Cytoband
q31.31
Reference genome
GRCh37/hg19
Start
118946560/119306506 (Hg38)
End
118946560/119306506 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/2286187; hsa-mir-10399/Downstream/7751582;
Nearest TSS
ENST00000635602/Upstream/1066531; ENST00000421825/Downstream/600869;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1091839, chr7-CpG: 93/Downstream/966280
Nearby gene
KCND2(No orient, 967162)
Upstream sequence
ggaggccaaggcgggtagatcacctgaggtcaggagtttgacataagcctggccaacatggtgaaaccctgtccctactaaaaatacaaaaattagccgg
Downstream sequence
atagccaaccaactaattaagaaaaaccaaggtcagatggattcacagctgcgttctaccagaggtacaaagaagaactgataccattcttactgaaact
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate