Basic Information
VIS ID
TVIS10006902
Fusion event
HBV-chr8 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
B2
Reference genome
JQ688405
Region type
Polymerase, X protein
Start
1615
Integrated sequence
ACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGAC| |CACCGTGAACGCCCACAGGAACCTGCCCAAGGTCTTGCATAAGAGGACTCTTGGACTTTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGAC
Host Sequence
Chromosome
chr8
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
37645249/37787731 (Hg38)
End
37645249/37787731 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/7830383; hsa-mir-10400/Downstream/3483317;
Nearest TSS
ENST00000518652/Upstream/3540; ENST00000412232/Downstream/9175;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/24479, chr8-CpG: 169/Downstream/8799
Nearby gene
PLPBP(No orient, 7963)
Upstream sequence
CCCCAAATTCTGCAGAAAATAAACATCCACTGTAAATATTTACTTCTGTGATTAAGAACAGAAGACACATGTAAATAGCACTGACACCTGCCTCGGAAAG
Downstream sequence
GAAAACCGGGAGGCCTGGTGGGCAGCTCCTAAATGCTGGATTGGAAAACCCATCCTCAAACAGGGTCGATCTCTCGGGGCGCTAAGCCCGTTCCATGACT
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate