Basic Information
VIS ID
TVIS10006906
Fusion event
HBV-chr4 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
JQ688404
Region type
Polymerase, X protein
Start
1591
Integrated sequence
CTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTT| |CACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACC
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
91044191/90123040 (Hg38)
End
91044191/90123040 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA4E
Nearest miRNA
hsa-mir-12113/Upstream/2822457; hsa-mir-1243/Downstream/8874347;
Nearest TSS
ENST00000502981/Upstream/171595; ENST00000508550/Downstream/4495;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/285321, chr4-CpG: 123/Downstream/4220
Nearby gene
DUX4L4(No orient, 30715)
Upstream sequence
tctcactccagtctgcagaactggcagcccggctgtcaggcttcagtctatccctggcttgaaggtgaggtttcactggggaccctgcccctttctaccc
Downstream sequence
TTTCTAATGGTGAATCTGTTTACAAAATTTTTTGTTTTATGTTAATAAACATTATTTTAACTCAGTTTTCCTCCCTTAATAAACAGAGAGGCTTAAATTC
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate