VISDB Viral Integration Site DataBase

VIS ID

TVIS10006907

Fusion event

HBV-EIF4G3 integration

Validated

Yes

Detection method

Alu PCR and sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2015

PubMed ID

Virus name

HBV

Subtype

C2

Reference genome

Region type

Polymerase, Pre-S2/S, S

Start

473

Integrated sequence

TGGATGTGTCTGCGGCGTTTTATCATATTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTACCAAGGTATGTTGCCCGTTT| |GTCCTCTACTTCCAGGAACATCAACTACCAGCACGGGACCATGCAAGACCTGCACGATTCCTGCTCAAGGAACCTCTATGTTTCCCTCTTGTTGCTGTAC

Chromosome

chr1

Cytoband

p36.12

Reference genome

Start

End

21485152/21158659 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-24-3p ; hsa-mir-16-5p ; hsa-mir-221-3p ; hsa-mir-17-5p ; hsa-mir-3613-3p ; hsa-mir-543 ; hsa-mir-136-5p ; hsa-mir-377-5p ; hsa-mir-218-5p ; hsa-mir-548c-3p ; hsa-mir-4724-3p ; hsa-mir-6813-3p ; hsa-mir-3200-3p

Nearest miRNA

hsa-mir-12136/Upstream/170227; hsa-mir-101-1/Downstream/1107580;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/371031, chr1-CpG: 77/Downstream/17963

Nearby gene

EMBP1(No orient, 171466)

Upstream sequence

TAGCTCCTCCAACTAAAACAATTATTCTGACCTGGTACACAAGATTTAACACCACTaaaacacaacataaactaggcacagtggcacacacttgtaatcc

Downstream sequence

cccctactcaagaagctgaggcagtagaattacctgaGTTTGAGTCCAACGGTGAGTATacacacgtacatacatatacatacacacacacacTCTCTCT