VISDB Viral Integration Site DataBase

VIS ID

TVIS10006912

Fusion event

HBV-MEMO1 integration

Validated

Yes

Detection method

Alu PCR and sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2015

PubMed ID

Virus name

HBV

Subtype

C2

Reference genome

Region type

Polymerase

Start

2477

Integrated sequence

ACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGA| |AACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTGAGTGGCAAACTCCCTCCTTTCCTCACATTCATTTACAGGAGGACATTATTAATA

Chromosome

chr2

Cytoband

p22.3

Reference genome

Start

End

32117435/31892366 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-4642 ; hsa-mir-580-3p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-3649 ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-657 ; hsa-mir-3665 ; hsa-mir-645 ; hsa-mir-4442 ; hsa-mir-3687 ; hsa-mir-4712-3p ; hsa-mir-6865-5p ; hsa-mir-6815-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-4797-5p ; hsa-mir-3929 ; hsa-mir-324-5p ; hsa-mir-129-5p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-4477a ; hsa-mir-2115-5p

Nearest miRNA

hsa-mir-1301/Upstream/3895917; hsa-mir-10b/Downstream/639787;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/310653, chr2-CpG: 174/Downstream/117218

Upstream sequence

TTCTTAAAATCCATAAATTAAATGTTTAAAGGGTACAAGGGTACGATTAAAAATATGAGTCATACAGAATACTAAAAATATCCATTTAAACTACAGAAAT

Downstream sequence

ATATACTACCTCTTTAGGTAAAAAAAGCTATTTTACTACCAGGTATAATAACATCTCAAAAAATAAAAACAAGCCCATCAGAAGAGCACCAATTCAATTC