VISDB Viral Integration Site DataBase

VIS ID

TVIS10006928

Fusion event

HBV-FRYL integration

Validated

Yes

Detection method

Alu PCR and sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2015

PubMed ID

Virus name

HBV

Subtype

C2

Reference genome

Region type

Polymerase; pre-S1/pre-S2/S

Start

2911

Integrated sequence

GTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCATGGGGACGAATCTTTCTGTTCCCAATCCTC| |TGGGATTCTTTCCCGATCACCAGTTGGACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTTCAACCCCAACAAGGATCACTGGCCAGAGGC

Chromosome

chr4

Cytoband

p11

Reference genome

Start

End

48750056/48748039 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-1261 ; hsa-mir-128-3p ; hsa-mir-216a-3p ; hsa-mir-224-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-3171 ; hsa-mir-3681-3p ; hsa-mir-3681-5p ; hsa-mir-376b-5p ; hsa-mir-376c-5p ; hsa-mir-6849-5p

Nearest miRNA

hsa-mir-12113/Upstream/1095296; hsa-mir-1243/Downstream/3964643;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/256467, chr4-CpG: 121/Downstream/31275

Upstream sequence

ggagaaaatggctaataaaaggtagaactgggactcaaacttaggccttcagacactaaagcccatgTGAAGTTTTTGTTTTGTTTTACTCTACTCCATA

Downstream sequence

gcttgagaccagcctggccaacatggggaaaccctgtctccaccaaaaatagaaaaattagctgggtgtggtggtgtgtgcctgtagtcccagctacttg