Basic Information
VIS ID
TVIS10006929
Fusion event
HBV-chr17 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
JQ688404
Region type
Polymerase, X protein
Start
509
Integrated sequence
ATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTACCAAGGTATGTTGCCCGTTTGTCCTCTACTTCCAGGAACATCAACTACCAGCACGG| |GACCATGCAAGACCTGCACGATTCCTGCTCAAGGAACCTCTATGTTTCCCTCTTGTTGCTGTACAAAACCTTCGGACGGAAACTGCACTTGTATTCCCAT
Host Sequence
Chromosome
chr17
Cytoband
q22
Reference genome
GRCh37/hg19
Start
54794533/56717172 (Hg38)
End
54794533/56717172 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10226/Upstream/5948442; hsa-mir-1250/Downstream/174098;
Nearest TSS
ENST00000595228/Upstream/123473; ENST00000572810/Downstream/78120;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/119301, chr17-CpG: 28/Downstream/63159
Nearby gene
NOG(No orient, 121582)
Upstream sequence
aacaagagtgaaactctgtctcaaaaaaaaaaaaaaaaaaagaaagaaagaaagagagagagagagagagaaagaaaTATTGAATTGCGACAGGCCAGGT
Downstream sequence
ACTCTGACAGAAATGTGTACTGTTTAGAAAGATAGCACAGAGGAGAAAGTAGCCAATTCATCCTGGGGGAGTCTGATGGATCGAACATTTCAACAAACAC
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate