Basic Information
VIS ID
TVIS10006934
Fusion event
HBV-chr8 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
JQ688404
Region type
pre-core/core, X protein
Start
1826
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATT
Host Sequence
Chromosome
chr8
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
53919293/53006733 (Hg38)
End
53919293/53006733 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/10110458; hsa-mir-10400/Downstream/8708055;
Nearest TSS
ENST00000518652/Upstream/68302; ENST00000529837/Downstream/170838;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/64867, chr8-CpG: 118/Downstream/244010
Nearby gene
NPBWR1(No orient, 65839)
Upstream sequence
atagagcagttttgagacactcttcttttggaatctgcaagtggatatttggctagatttgaggatttcgttggaaacgggattatatataaaaagtaga
Downstream sequence
GAGCCAGGATGCGATTCAGCTCTCAACAGGGGACTGTGATTAGCTGTTTGCCCAGGAGGAGGCAAGACAAAATGAGACCTGGGGACACGTTACCAGGGAA
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate