Basic Information
VIS ID
TVIS10006937
Fusion event
HBV-chr8 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
JQ688404
Region type
Polymerase
Start
1357
Integrated sequence
CTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCTGTTGTCCTCTCTCGGA| |AATACACCTCCTTTCCATGGCTGCTAGGGTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGA
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
142911585/141830224 (Hg38)
End
142911585/141830224 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA8D
Nearest miRNA
hsa-mir-1204/Upstream/43911; hsa-mir-10400/Downstream/346115;
Nearest TSS
ENST00000518652/Upstream/315527; ENST00000562989/Downstream/259603;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/69428, chr8-CpG: 18/Downstream/72838
Nearby gene
MIR4472-1(No orient, 346115)
Upstream sequence
ttgatagagcagttttgagacactcttcttttggaatctgcaagtggatatttggatagatttgaggatttcgttggaaacgggattatatatcaaaagt
Downstream sequence
ttactgcagcacagcctagctttccctgattaatacaCATAGCCTCAAGGACATGGGTGAAGAAATGAAGACATTATCTGGGCAGAGGATCCCATTTATA
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate