Fusion event
HBV-TERT integration
Detection method
Alu PCR and sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GACGCAACCCCCACTGGTTGGGGCTTGGCCATAGGCCATCAGCGCATGCGTGGAACCTTTGTGTCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCG| |CTTGTTTTGCTCGCAGCAGGTCTGGGGCAAAACTCATCGGGACTGACAATTCTGTCGTGCTCTCCCGCAAGTATACATCATTTCCATGGCTGCTAGGCTG
End
1295534/1295419 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-4635/Upstream/232445; hsa-mir-10397/Downstream/13891;
Nearest cancer related gene
Upstream sequence
GCCCAGCAGTAGAAGCCACACGGCCACTGGTCCCCTCCAGACCTGGGGCCCCGGCACAACCGCAGGACAGCTGAGGACTTCCCAGGAATCCAGACTCCGG
Downstream sequence
GTGGGGTAACCCGAGGGAGGGGCCATGATGTGGAGGCCCTGGGAACAGGTGCGTGCGGCGACCCTTTGGCCGCTGGCCTGATCCGGAGACCCAGGGCTGC
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.