Basic Information
VIS ID
TVIS10006951
Fusion event
HBV-MIR4457 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
JQ688404
Region type
Polymerase, Pre-S2/S, S
Start
9
Integrated sequence
CTCCACAAC| |ATTCCACCAAGCTCTGCTAGATCCCAGAGTGAGGGGCCTATATTTTCCTGCTGGTGGCTCCAGTTCCGGAACAGTAAACCCTGTTCCGACTACTGCCTCA
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
1307384/1307269 (Hg38)
End
1307384/1307269 (Hg38)
Location type
Promoter
Target gene
MIR4457
Nearest miRNA
hsa-mir-4635/Upstream/244295; hsa-mir-10397/Downstream/2041;
Nearest TSS
ENST00000502646/Upstream/12200; ENST00000605200/Downstream/14560;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/11414, chr5-CpG: 18/Downstream/27693
Upstream sequence
GAGGGCAACCTCGGGGTCCAGGCACCTGGCTCCAAGCCTCGGACTGCAGAGCTAGGAGGCCCGACTTCCAGCCCAGCAGTAGAAGCCACACGGCCACTGG
Downstream sequence
gacttataTGTGCCATGAGATTTGGAAAGGTGCCCAGCCAAAAGTTTTTTtatatatttatatatatatgtatatacgtatatacatttatatatatacg
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate