Basic Information
VIS ID
TVIS10006963
Fusion event
HBV-chr5 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
JQ688404
Region type
pre-core/core
Start
2148
Integrated sequence
CTCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGA| |ATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTGGAAGAGAAACTGTTCTT
Host Sequence
Chromosome
chr5
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
61056203/61760376 (Hg38)
End
61056203/61760376 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA5H
Nearest miRNA
hsa-mir-10397/Upstream/2056673; hsa-mir-103a-1/Downstream/10409091;
Nearest TSS
ENST00000502646/Upstream/24707; ENST00000511474/Downstream/117733;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/133731, chr5-CpG: 141/Downstream/545414
Nearby gene
GABRB2(No orient, 81073)
Upstream sequence
CCACACATGAAAACCAATCCCACAGATCCCCACCTACCCCACGGATGAAAACCAATTCACAGATCCCCACCTACCCCACACATAAAAACCAATCCCACAG
Downstream sequence
ttgaactagctaggacttccagtacaattccagtaataaaagtaatgtaagtggaaccgcttctcttgtatccagtcttaagtggagggcattcagtgct
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
Curate