Basic Information
VIS ID
TVIS10006965
Fusion event
HBV-ADGRF5 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
JQ688404
Region type
Polymerase,S
Start
489
Integrated sequence
GTTTTATCATATTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTACCAAGGTATGTTGCCCGTTTGTCCTCTACTTCCAGG| |AACATCAACTACCAGCACGGGACCATGCAAGACCTGCACGATTCCTGCTCAAGGAACCTCTATGTTTCCCTCTTGTTGCTGTACAAAACCTTCGGACGGA
Host Sequence
Chromosome
chr6
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
46816782/46849045 (Hg38)
End
46816782/46849045 (Hg38)
Location type
Promoter
Target gene
ADGRF5
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10398/Upstream/1651275; hsa-mir-10524/Downstream/5295304;
Nearest TSS
ENST00000381078/Upstream/55646; ENST00000451135/Downstream/14259;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/113466, chr6-CpG: 123/Downstream/459674
Upstream sequence
taaataatcactggcttcaactgaaagtcactggatacattggcctctaacaggagagtcagcctgtcttttgaagctttgaagcagatgttgacttctt
Downstream sequence
ATCCGCGGGACTGACTGCCTCCCGCCGGCTTCCTGAGGCCGGACCGCAGCGGGGACGCCTCCTCTCAGGCCCAGCAGGGGGCGCGCGAGCCTCAGGAGAC
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
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