VISDB Viral Integration Site DataBase

VIS ID

TVIS10006970

Fusion event

HBV-STAT1 integration

Validated

Yes

Detection method

Alu PCR and sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2015

PubMed ID

Virus name

HBV

Subtype

C2

Reference genome

Region type

Polymerase;HBVgp2 pre-S1/pre-S2/S

Start

2936

Integrated sequence

AGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCATGGGGACGAATCTTTCTGTTCCCAATCCTCTGGGATTCTTTCCCGATCACCAGTT| |GGACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTTCAACCCCAACAAGGATCACTGGCCAGAGGCAAATCAGGTAGGAGCGGGAGCATTC

Chromosome

chr2

Cytoband

q32.2

Reference genome

Start

End

191836387/190971661 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-145-5p ; hsa-mir-146a-5p ; hsa-mir-34a-5p ; hsa-mir-615-3p ; hsa-mir-653-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-4693-5p ; hsa-mir-5009-3p ; hsa-mir-501-5p ; hsa-mir-1183 ; hsa-mir-500a-5p ; hsa-mir-605-5p ; hsa-mir-140-5p ; hsa-mir-150-5p ; hsa-mir-223-3p ; hsa-mir-203a-3p ; hsa-mir-450a-5p ; hsa-mir-155-5p

Nearest miRNA

hsa-mir-10b/Upstream/1838550; hsa-mir-1244-1/Downstream/15811573;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/89788, chr2-CpG: 70/Downstream/42221

Nearest cancer related gene

STAT1(TSG, No orient, 0)

Upstream sequence

AGCCTCTGGAGAACTTTTTTTTAATCCCAAGTGCTCAATAGTGTGTGGTACATAGTGGGCTCTTAGGAAAATTATTTTGGATTGAAAAGCACAGTGAAAG

Downstream sequence

TGTTGCCCCTATGTTTCAGTCTAGCTTATGTTTCTCttttctttttctttctttttttttttcaaattggagacggagtcttcctctgttgcccagactg