VISDB Viral Integration Site DataBase

VIS ID

TVIS10006973

Fusion event

HBV-TERT integration

Validated

Yes

Detection method

Alu PCR and sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2015

PubMed ID

Virus name

HBV

Subtype

B2

Reference genome

Region type

Polymerase; X protein

Start

1442

Integrated sequence

TCGTGCTCTCCCGCAAGTATACATCATTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCT| |GAATCCCGCGGACGACCCCTCCCGGGGCCGCTTGGGGCTCTACCGCCCGCTTCTCCGCCTGTTGTACCGACCGACCACGGGGCGCACCTCTCTTTACGCG

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1295541/1295426 (Hg38)

Location type

Promoter

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/232452; hsa-mir-10397/Downstream/13884;

Nearest TSS

Nearest CpG islands

chr5-CpG: 485/Target, None/Upstream, None/Downstream

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

GACTAAGCACGCTTGGATAATGGCCGGGGGCTGAATGCTGCTGAACAGTAAAGAGCATAGATGCCAAAGGTCATAATCAGAGATGGGCTGGAGAAGAAGG

Downstream sequence

AACCCGAGGGAGGGGCCATGATGTGGAGGCCCTGGGAACAGGTGCGTGCGGCGACCCTTTGGCCGCTGGCCTGATCCGGAGACCCAGGGCTGCCTCCAGG