VISDB Viral Integration Site DataBase

VIS ID

TVIS10006978

Fusion event

HBV-ST18 integration

Validated

Yes

Detection method

Alu PCR and sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2015

PubMed ID

Virus name

HBV

Subtype

C2

Reference genome

Region type

Polymerase, X protein

Start

1589

Integrated sequence

CCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGC| |TTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGA

Chromosome

chr8

Cytoband

q11.23

Reference genome

Start

End

53048426/52135866 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-580-3p ; hsa-mir-451b ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-3691-5p ; hsa-mir-376b-5p ; hsa-mir-376c-5p ; hsa-mir-3911 ; hsa-mir-4711-3p ; hsa-mir-4752 ; hsa-mir-496 ; hsa-mir-574-5p ; hsa-mir-627-5p ; hsa-mir-6744-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-8056 ; hsa-mir-924

Nearest miRNA

hsa-mir-124-1/Upstream/9239591; hsa-mir-10400/Downstream/9578922;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/236114, chr8-CpG: 117/Downstream/429118

Upstream sequence

gagcttgcagtgaatcgagatcatgccactgcactctagcttgcgtgacgcaactccgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaatttttcact

Downstream sequence

AGTAGATGTAGTAATACTCATTTTTTCTAAAGCTTTATTATTTGTAAAAAGATGTAATTAGTTTTGTTTAATCCTATTTCTTTATCTTTTAAAATTTATG