Basic Information
VIS ID
TVIS10006985
Fusion event
HBV-chr16 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25627239
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
JQ688404
Region type
Polymerase,S
Start
504
Integrated sequence
TCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTACCAAGGTATGTTGCCCGTTTGTCCTCTACTTCCAGGAACATCAACTACCAG| |CACGGGACCATGCAAGACCTGCACGATTCCTGCTCAAGGAACCTCTATGTTTCCCTCTTGTTGCTGTACAAAACCTTCGGACGGAAACTGCACTTGTATT
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
69535/19535 (Hg38)
End
69535/19535 (Hg38)
Nearest miRNA
hsa-mir-6859-4/Upstream/2416; hsa-mir-11401/Downstream/515781;
Nearest TSS
ENST00000527434/Downstream/3375;
Nearest CpG islands
None/Target, None/Upstream, chr16-CpG: 29/Downstream/3308
Nearby gene
DDX11L10(-1444) ; WASIR2(+3381) ;
Upstream sequence
GCACCATCTCCTTCCAGTGAGGAAGCGGGGCCACCACCCAGCGTGTGCTCCATCTTTTCTGGCTGGGGAGAGGCCTTCATCTGCTGTAAAGGGTcctcac
Downstream sequence
cctgaccctgaccctcaccctgaccctgaccctaaaaccctgaccctaaaaccctgaccctaaccctgaccctgaccctaaccctgaccctgaccctaac
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.
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