Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006988
Fusion event
HBV-DNAH14 integration
Validated
Yes
Detection method
Alu PCR and sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C2
Reference genome
Region type
Polymerase, X protein
Start
1423
Integrated sequence
ATCGGAACCGACAACTCTGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGGTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTG| |TCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGACTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGG
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
Start
End
25241058/24914567 (Hg38)
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-12136/Upstream/985420; hsa-mir-101-1/Downstream/4778;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/6251, chr1-CpG: 357/Downstream/14469
Upstream sequence
TCTGCTGTGAATCGGCCCCCTGTGAGCAGATGAAAGCCGGGTCGGTGGCTGGGCAGGGAAACGGGCTGGCCGGGGGCCAGCGGGCAGGGAGGCGAGCGGT
Downstream sequence
TCCCTCCCAGGGCTGCAAGTGGGGCTTCCAGAGGCCTGGGGTTGATTAGGAGAACCCAGGAGGTCTGTGGTTAACCCCTTCCCTCCTGCTGGGCAGACTC
Reference
Yan, H., et al. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Hepatology ,2015,61(6): 1821-1831.