VISDB Viral Integration Site DataBase

VIS ID

TVIS10006989

Fusion event

HBV-STXBP4 integration

Validated

Yes

Detection method

Alu PCR and sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2015

PubMed ID

Virus name

HBV

Subtype

C2

Reference genome

Region type

Polymerase, X protein

Start

1461

Integrated sequence

CACCTCCTTTCCATGGCTGCTAGGGTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCG| |TCTCGGGGCCGTTTGGGACTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTT

Chromosome

chr17

Cytoband

p13.3

Reference genome

Start

End

3048162/3144868 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-192-5p ; hsa-mir-324-5p ; hsa-mir-7702 ; hsa-mir-151a-3p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-4448 ; hsa-mir-3670 ; hsa-mir-556-5p

Nearest miRNA

hsa-mir-1253/Upstream/396686; hsa-mir-10226/Downstream/1824834;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/95789, chr17-CpG: 81/Downstream/241200

Upstream sequence

attgatctttacaaagaaccgggtcttcgcttctttgatttttctctgttgttttttatgttcaatttcattgatttttgatcctatcattattacttcc

Downstream sequence

ttccttgtgtttgctttgaatttattttgctcttttctaggcttcttaaatgggaacttagattattgatttgagactttcctcttttctaatgtatgta